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The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT).
Pharaoh G, Kamat V, Kannan S, Stuppard RS, Whitson J, Martín-Pérez M, Qian WJ, MacCoss MJ, Villén J, Rabinovitch P, Campbell MD, Sweet IR, Marcinek DJ. Pharaoh G, et al. Among authors: stuppard rs. Geroscience. 2023 Dec;45(6):3529-3548. doi: 10.1007/s11357-023-00861-y. Epub 2023 Jul 18. Geroscience. 2023. PMID: 37462785 Free PMC article.
Elamipretide Improves ADP Sensitivity in Aged Mitochondria by Increasing Uptake through the Adenine Nucleotide Translocator (ANT).
Pharaoh G, Kamat V, Kannan S, Stuppard RS, Whitson J, Martin-Perez M, Qian WJ, MacCoss MJ, Villen J, Rabinovitch P, Campbell MD, Sweet IR, Marcinek DJ. Pharaoh G, et al. Among authors: stuppard rs. bioRxiv [Preprint]. 2023 Feb 3:2023.02.01.525989. doi: 10.1101/2023.02.01.525989. bioRxiv. 2023. PMID: 36778398 Free PMC article. Updated. Preprint.